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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • IRAK2 Antibodies

          Invitrogen

          IRAK2 Polyclonal Antibody

          View all (13) IRAK2 antibodies
          Datasheet
          Protocols
          Tech Support

          Cite IRAK2 Polyclonal Antibody

          Datasheet
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          • Antibody Testing Data (1)
          IRAK2 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          IRAK2 Antibody (PA5-96204) in WB

          Western blot analysis of IRAK2 in extracts of Mouse liver. Samples were incubated with IRAK2 Polyclonal antibody (Product # PA5-96204) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Product Details

          PA5-96204

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1:500-1:2,000
          -
          产品规格

          Species Reactivity

          Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human IRAK2.
          View immunogen

          Conjugate

          Unconjugated

          形式

          Liquid

          浓度

          0.15 mg/mL

          纯化类型

          Affinity Chromatography

          保存液

          PBS, pH 7.3, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20° C, Avoid Freeze/Thaw Cycles

          RRID

          AB_2808006

          Product Specific Information

          Immunogen sequence: MACYIYQLPS WVLDDLCRNM DALSEWDWME FASYVITDLT QLRKIKSMER VQGVSITREL LWWWGMRQAT VQQLVDLLCR LELYRAAQII LNWKPAPEIR CPIPAFPDSV KPEKPLAASV RKAEDEQEEG QPVRMATFPG PGSSPARAHQ PAFLQPPEED APHSLRSDLP TSSDSKDFST SIPKQEKLLS LAGDSLFWSE ADVVQATDDF NQNRKISQGT FADVYRGHRH GKPFVFKKLR ETACSSPGSI ERFFQAELQI CLRCCHPNVL; Positive Samples: Mouse liver

          Target Information

          IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          Cite this product

          Bioinformatics

          Protein Aliases: interleukin-1 receptor-associated kinase 2c; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; MGC150550; mu-IRAK-2

          View more View less

          Gene Aliases: 6330415L08Rik; AI649099; IRAK-2; Irak2

          View more View less

          UniProt ID: (Mouse) Q8CFA1, (Rat) Q4QQS0

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          Entrez Gene ID: (Mouse) 108960, (Rat) 362418

          View more View less

          Function(s)
          regulation of cytokine-mediated signaling pathway toll-like receptor signaling pathway protein phosphorylation signal transduction activation of NF-kappaB-inducing kinase activity lipopolysaccharide-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity intracellular signal transduction regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity protein autophosphorylation positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway response to interleukin-1 biological_process
          Process(es)
          nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding transferase activity, transferring phosphorus-containing groups protein homodimerization activity protein heterodimerization activity molecular_function
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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