Invitrogen

IRAK4 Polyclonal Antibody

Name: IRAK4 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-29699

高级验证

查看其他29个IRAK4抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (5)
高级验证 (2)

IRAK4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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IRAK4 Antibody (PA5-29699) in IHC (P)

IRAK4 Polyclonal Antibody detects IRAK4 protein at cytosol on human gastric cancer by immunohistochemical analysis. Sample: Paraffin-embedded human gastric cancer. IRAK4 Polyclonal Antibody (Product # PA5-29699) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

Product Image Gallery

IRAK4 Antibody — Antibody specificity was demonstrated by siRNA mediated KD of target protein. THP-1 cells were transfected with IRAK4 siRNA and decrease in signal intensity was observed in Western Blot application using Anti-IRAK4 Polyclonal Antibody (Product # PA5-29699). {KD}

产品信息

PA5-29699

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human IRAK4. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.54 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2547173

产品详细信息

Recommended positive controls: H1299.

Predicted reactivity: Mouse (89%), Rat (90%), Pig (95%), Sheep (93%), Rhesus Monkey (100%), Bovine (94%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。