Invitrogen

IRF1 Polyclonal Antibody

查看其他15个IRF1抗体

产品信息

PA5-50512

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-
免疫组化（石蜡） (IHC (P))	1:50-1:200	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to a region derived from internal residues of human interferon regulatory factor 1
偶联物	Unconjugated
形式	Liquid
浓度	1.5 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635965

产品详细信息

The antibody detects endogenous levels of total IRF1 protein.

靶标信息

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. Diseases associated with IRF1 include gastric cancer, somatic and lung cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Interferon regulatory factor 1; interferon regulatory factor 1 isoform +I9; interferon regulatory factor 1 isoform d78; interferon regulatory factor 1 isoform delta4; interferon regulatory factor 1 isoform delta7; IRF-1

基因别名: AU020929; IRF-1; IRF1; MAR

UniProt ID: (Human) P10914, (Mouse) P15314

Entrez Gene ID: (Human) 3659, (Mouse) 16362

分子生物学功能: winged helix/forkhead transcription factor

regulation of adaptive immune response transcription from RNA polymerase II promoter apoptotic process cell cycle arrest blood coagulation negative regulation of cell proliferation positive regulation of type I interferon production positive regulation of interferon-beta production regulation of MyD88-dependent toll-like receptor signaling pathway cellular response to interferon-beta CD8-positive, alpha-beta T cell differentiation positive regulation of interleukin-12 biosynthetic process regulation of innate immune response negative regulation of regulatory T cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter defense response to virus regulation of cell cycle interferon-gamma-mediated signaling pathway type I interferon signaling pathway cellular response to mechanical stimulus regulation of CD8-positive, alpha-beta T cell proliferation immune system process transcription, DNA-templated regulation of transcription, DNA-templated I-kappaB kinase/NF-kappaB signaling regulation of gene expression positive regulation of cell death positive regulation of natural killer cell differentiation negative regulation of tyrosine phosphorylation of Stat1 protein innate immune response positive regulation of T-helper 1 cell differentiation negative regulation of T-helper 2 cell differentiation response to growth hormone cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to peptide hormone stimulus

参与通路

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding regulatory region DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding