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Invitrogen
IRF8 Polyclonal Antibody
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产品信息
PA1-31665
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence QRSFFRENQQITV, from C Terminus of the protein sequence according to NP_002154
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-31665 detects ICSBP from human samples.
PA1-31665 has been successfully used in Western blot applications.
The PA1-31665 immunogen is: Peptide with sequence QRSFFRENQQITV, from C Terminus of the protein sequence according to NP_002154
靶标信息
IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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