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Invitrogen
IRGC Polyclonal Antibody
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产品信息
PA5-20790
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
a 12 amino acid peptide near the carboxy terminus of human IRGC.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is mouse brain tissue lysate.
PA5-20790 can be used with blocking peptide PEP-0904.
靶标信息
Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cinema 1; Immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon inducible GTPase family member 5; interferon-gamma-inducible GTPase IFGGE protein; Interferon-inducible GTPase 5
基因别名: CINEMA; F630044M05Rik; Gm1102; Gm474; IFGGE; IIGP5; IRGC; IRGC1; R30953_1; RGD1311107
UniProt ID: (Human) Q6NXR0, (Rat) Q6AYF9
Entrez Gene ID: (Human) 56269, (Rat) 308428, (Mouse) 210145
