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Proteintech
IRS1 Polyclonal Antibody
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产品信息
17509-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Fish,
Human,
Mouse,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
IRS1 Fusion Protein Ag11714 (895-1243 aa encoded by BC053895)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EYVNIEFGS DQSGYLSGPV AFHSSPSVRC PSQLQPAPRE EETGTEEYMK MDLGPGRRAA WQESTGVEMG RLGPAPPGAA SICRPTRAVP SSRGDYMTMQ MSCPRQSYVD TSPAAPVSYA DMRTGIAAEE VSLPRATMAA ASSSSAASAS PTGPQGAAEL AAHSSLLGGP QGPGGMSAFT RVNLSPNRNQ SAKVIRADPQ GCRRRHSSET FSSTPSATRV GNTVPFGAGA AVGGGGGSSS SSEDVKRHSS ASFENVWLRP GELGGAPKEP AKLCGAAGGL ENGLNYIDLD LVKDFKQCPQ ECTPEPQPPP PPPPHQPLGS GESSSTRRSS EDLSAYASIS FQKQPEDRQ (895-1243 aa encoded by BC053895)
靶标信息
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Insulin receptor substrate 1; IRS-1
基因别名: HIRS-1; IRS1
UniProt ID: (Human) P35568
Entrez Gene ID: (Human) 3667
signal transducer activity
transmembrane receptor protein tyrosine kinase adaptor activity
protein kinase C binding
Ras guanyl-nucleotide exchange factor activity
insulin receptor binding
insulin-like growth factor receptor binding
protein binding
1-phosphatidylinositol-3-kinase activity
SH2 domain binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MAPK cascade
signal transduction
positive regulation of cell proliferation
insulin receptor signaling pathway
positive regulation of glucose metabolic process
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of fatty acid beta-oxidation
response to insulin
cellular response to insulin stimulus
phosphatidylinositol-3-phosphate biosynthetic process
glucose homeostasis
response to peptide hormone
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of glucose import in response to insulin stimulus
