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Proteintech
ITCH Monoclonal Antibody (2E3G9), CoraLite® Plus 488
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产品信息
CL488-67757
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2E3G9
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: TLFEDSFQQI MSFSPQDLRR RLWVIFPGEE GLDYGGVARE WFFLLSHEVL NPMYCLFEYA GKDNYCLQIN PASYINPDHL KYFRFIGRFI AMALFHGKFI DTGFSLPFYK RILNKPVGLK DLESIDPEFY NSLIWVKENN IEECDLEMYF SVDKEILGEI KSHDLKPNGG NILVTEENKE EYIRMVAEWR LSRGVEEQTQ AFFEGFNEIL PQQYLQYFDA KELEVLLCGM QEIDLNDWQR HAIYRHYART SKQIMWFWQF VKEIDNEKRM RLLQFVTGTC RLPVGGFADL MGSNGPQKFC IEKVGKENWL PRSHTCFNRL DLPPYKSYEQ LKEKLLFAIE ETEGFGQE
靶标信息
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AIP4; atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; dJ468O1.1; E3 ubiquitin-protein ligase Itchy; E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; Itch; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase homolog; itchy, E3 ubiquitin protein ligase; NAPP1; NFE2-associated polypeptide 1
基因别名: 6720481N21Rik; 8030492O04Rik; A130065M08; ADMFD; AIF4; AIP4; C230047C07Rik; ITCH; NAPP1
UniProt ID: (Human) Q96J02, (Mouse) Q8C863
Entrez Gene ID: (Human) 83737, (Mouse) 16396, (Rat) 311567
ubiquitin-protein transferase activity
protein binding
ligase activity
ubiquitin-like protein transferase activity
ribonucleoprotein complex binding
CXCR chemokine receptor binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
regulation of cell growth
positive regulation of T cell anergy
ubiquitin-dependent protein catabolic process
apoptotic process
inflammatory response
Notch signaling pathway
protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
protein K29-linked ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
innate immune response
positive regulation of protein catabolic process
negative regulation of JNK cascade
negative regulation of alpha-beta T cell proliferation
viral entry into host cell
negative regulation of defense response to virus
defense response to virus
nucleotide-binding oligomerization domain containing signaling pathway
protein K63-linked ubiquitination
protein K48-linked ubiquitination
regulation of protein deubiquitination
protein polyubiquitination
immune system process
