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产品信息
PA5-50688
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:50-1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to a region derived from internal residues of human inositol 1,4,5-trisphosphate receptor, type 3 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
2.7 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636140 |
产品详细信息
The antibody detects endogenous levels of total ITPR3 protein.
靶标信息
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor, type 3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
基因别名: IP3R; IP3R3; ITPR3
UniProt ID: (Human) Q14573
Entrez Gene ID: (Human) 3710
分子生物学功能:
ligand-gated ion channel
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
memory
platelet activation
inositol phosphate-mediated signaling
regulation of insulin secretion
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
release of sequestered calcium ion into cytosol
protein homooligomerization
protein heterooligomerization
response to calcium ion
long-term synaptic potentiation
calcium ion transport into cytosol
cellular response to cAMP
regulation of cardiac conduction
