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Invitrogen
ITPR3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88758
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2.23 mg/mL
规格
223 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: HeLa, LO2, HepG2; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
靶标信息
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: inositol 1,4,5-triphosphate receptor, type 3; Inositol 1,4,5-trisphosphate receptor type 3; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R-3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
基因别名: CMT1J; IMD132; IMD133; IP3R; IP3R-3; IP3R3; Itpr-3; ITPR3
UniProt ID: (Mouse) P70227
Entrez Gene ID: (Human) 3710, (Mouse) 16440
inositol hexakisphosphate binding
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
zinc ion binding
calcium-release channel activity
phosphatidylinositol binding
inositol 1,3,4,5 tetrakisphosphate binding
inositol 1,4,5 trisphosphate binding
ligand-gated ion channel
ion transport
calcium ion transport
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
calcium-mediated signaling
platelet activation
sensory perception of taste
release of sequestered calcium ion into cytosol
protein homotetramerization
response to calcium ion
calcium ion homeostasis
transmembrane transport
calcium ion transmembrane transport
transport
memory
inositol phosphate-mediated signaling
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
protein homooligomerization
protein heterooligomerization
long-term synaptic potentiation
calcium ion transport into cytosol
cellular response to cAMP
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
