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Interferon-activable protein 204 belongs to the HIN-200 family, which contains one DAPIN domain and two HIN-200 domains. It is reported to inhibit transcription of ribosomal RNA and thus acts as a multifunctional regulator of cell proliferation and differentiation. It is reported to act as a transcriptional coactivator of Cbfa1 (Core binding factor alpha-1) and enhances osteoblast differentiation. It enables skeletal muscle and cardiac myocyte differentiation by sequestering Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. It is also reported that Ifi204 is trancriptionally activated in response to M-CSF and thus involved in macrophage differentiation in myeloid progenitor cells.
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蛋白别名: Ifi-204; interferon, gamma-inducible gene 204; interferon, gamma-inducible protein 16; Interferon-activable protein 204; Interferon-inducible protein p204
基因别名: Ifi16; Ifi204; p204
UniProt ID: (Mouse) P0DOV2
Entrez Gene ID: (Mouse) 15951
分子生物学功能:
DNA-binding transcription factor
gene-specific transcriptional regulator
