Bioss

Integrin Alpha V + Beta 5 Polyclonal Antibody

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说明书
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说明书
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产品信息

BS-1356R

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1:400
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

流式细胞分析 (Flow)

1:100
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alpha v integrin; antigen identified by monoclonal antibody L230; CD51; Dnmt3l-ps1 pseudogene; integrin alpha V; Integrin alpha-V; integrin alphaVbeta3; integrin beta 5; Integrin beta-5; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 5; testis secretory sperm-binding protein Li 217p; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha

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基因别名: 1110004F14Rik; 2610028E01Rik; [b]-5; [b]5; [b]5A; [b]5B; AA475909; AI874634; beta-5; beta5; CD51; D430040G12Rik; ESTM23; ITGAV; ITGB5; MSK8; RGD1563276; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P18084, (Mouse) P43406, (Mouse) O70309

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Entrez Gene ID: (Human) 3685, (Human) 3693, (Rat) 296456, (Mouse) 16410, (Rat) 257645, (Mouse) 16419

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功能
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding voltage-gated calcium channel activity protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding receptor binding peptide binding protein heterodimerization activity integrin binding receptor activity integrin
参与通路
angiogenesis antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent cell adhesion cell-matrix adhesion integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage cell growth cell migration extracellular matrix organization positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of cell adhesion viral entry into host cell vascular endothelial growth factor receptor signaling pathway negative regulation of lipoprotein metabolic process regulation of phagocytosis leukocyte migration negative chemotaxis entry of symbiont into host cell by promotion of host phagocytosis ERK1 and ERK2 cascade calcium ion transmembrane transport extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic cell clearance negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway muscle contraction transforming growth factor beta receptor signaling pathway stress fiber assembly epithelial cell-cell adhesion blood vessel development vasculogenesis cellular calcium ion homeostasis positive regulation of cytosolic calcium ion concentration positive regulation of MAPK cascade inflammatory response multicellular organism development fertilization cell differentiation detection of molecule of bacterial origin regulation of ion transmembrane transport gonad morphogenesis T cell activation endothelial cell migration regulation of bone resorption focal adhesion assembly release of sequestered calcium ion into cytosol trophoblast giant cell differentiation response to nitric oxide biological_process
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