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Integrin alpha 2 Polyclonal Antibody

查看其他49个CD49b (Integrin alpha 2)抗体

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Integrin alpha 2 Polyclonal Antibody

产品信息

30703-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:8,000
-

免疫细胞化学 (ICC/IF)

1:200-1:800
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Integrin alpha 2 fusion protein Ag32771
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.6 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: GIVVDFSENL FFASFSLPVD GTEVTCQVAA SQKSVACDVG YPALKREQQV TFTINFDFNL QNLQNQASLS FQALSESQEE NKADNLVNLK IPLLYDAEIH LTRSTNINFY EISSDGNVPS IVHSFEDVGP KFIFSLKVTT GSVPVSMATV IIHIPQYTKE KNPLMYLTGV QTDKAGDISC NADINPLKIG QTSSSVSFKS ENFRHTKELN CRTASCSNVT CWLKDVHMKG EYFVNVTTRI WNGTFASSTF QTVQLTAAAE INTYNPEIYV IEDNTVTIPL MIMKPDEKAE VPT

靶标信息

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alpha 2 subunit of VLA-2 receptor; BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; human platelet alloantigen system 5; Integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet antigen Br; platelet glycoprotein GPIa; Platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2 subunit alpha; VLA2 receptor

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基因别名: BR; CD49B; GPIa; HPA-5; ITGA2; VLA-2; VLAA2

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UniProt ID: (Human) P17301

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Entrez Gene ID: (Human) 3673

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功能
virus receptor activity integrin binding protein binding collagen binding protein complex binding collagen receptor activity laminin binding metal ion binding protein heterodimerization activity collagen binding involved in cell-matrix adhesion integrin
参与通路
response to hypoxia positive regulation of leukocyte migration substrate-dependent cell migration hypotonic response cell adhesion cell-matrix adhesion integrin-mediated signaling pathway female pregnancy blood coagulation cell proliferation organ morphogenesis positive regulation of epithelial cell migration positive regulation of alkaline phosphatase activity response to amine response to muscle activity positive regulation of smooth muscle cell migration extracellular matrix organization mammary gland development positive regulation of cell projection organization cell-substrate adhesion positive regulation of collagen biosynthetic process positive regulation of collagen binding response to L-ascorbic acid cell adhesion mediated by integrin collagen-activated signaling pathway response to drug positive regulation of DNA binding skin morphogenesis establishment of protein localization positive regulation of translation positive regulation of cell adhesion positive regulation of smooth muscle contraction viral entry into host cell focal adhesion assembly mesodermal cell differentiation positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of positive chemotaxis detection of mechanical stimulus involved in sensory perception of pain positive regulation of transmission of nerve impulse positive regulation of phagocytosis, engulfment hepatocyte differentiation response to parathyroid hormone cellular response to mechanical stimulus cellular response to estradiol stimulus
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