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Invitrogen
Ivermectin Recombinant Mouse Monoclonal Antibody (1H2)
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Ivermectin Antibody (MA566445) in SDS-PAGE
SDS-PAGE characterization of Ivermectin under reducing conditions. Lane M: Protein marker (kDa); Lane IVM: Purified Ivermectin Recombinant Monoclonal (Product # MA566445). Ivermectin showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-459.
产品信息
MA566445
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1H2
抗原
Conjugate of IVM hapten and KLH.
偶联物
形式
Liquid
浓度
11.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Ivermectin is a macrolide antiparasitic drug characterized by a 16-membered macrocyclic lactone ring structure, widely recognized for its broad-spectrum antiparasitic activity and low toxicity. Developed by Satoshi Omura and William C. Campbell, who were awarded the Nobel Prize in Physiology or Medicine in 2015 for its discovery, ivermectin has been instrumental in treating various parasitic diseases such as river blindness, elephantiasis, and scabies. Its mechanism of action involves binding to glutamate-gated chloride channels in nerve and muscle cells of parasites, leading to paralysis and death of the parasite. Recent research has explored its potential anticancer properties and the synthesis of novel ivermectin derivatives, highlighting its multifaceted therapeutic applications beyond its traditional use in parasitology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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