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Proteintech
JAKMIP1 Polyclonal Antibody
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产品信息
13846-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
JAKMIP1 Fusion Protein Ag4816 (277-626 aa encoded by BC047075)
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: VQDQHMDER DVRRFQLKIA ELNSVIRKLE DRNTLLADER NELLKRSRET EVQLKPLVEK NKRMNKKNED LLQSIQRMEE KIKNLTRENV EMKEKLSAQA SLKRHTSLND LSLTRDEQEI EFLRLQVLEQ QHVIDDLSLE RERLLRSKRH RGKSLKPPKK HVVETFFGFD EESVDSETLS ETSYNTDRTD RTPATPEEDL DDATAREEAD LRFCQLTREY QALQRAYALL QEQVGGTLDA EREARTREQL QADLLRCQAK IEDLEKLLVE KGQDSKWVEE KQLLIRTNQD LLEKIYRLEM EENQLKNEMQ DAKDQNELLE FRVLELEVRD SICCKLSNGA DILFEPKLKF M (277-626 aa encoded by BC047075)
靶标信息
JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ31564; GABA-B receptor-binding protein; gamma-aminobutyric acid (GABA-B) receptor binding protein; Jak and microtubule interacting protein 1; Janus kinase and microtubule-interacting protein 1; Marlin-1; Multiple alpha-helices and RNA-linker protein 1; multiple coiled-coil GABABR1-binding protein
基因别名: 5830437M04Rik; C330021K24Rik; GABABRBP; JAKMIP1; JAMIP1; Marlin-1; MARLIN1
UniProt ID: (Human) Q96N16, (Mouse) Q8BVL9
Entrez Gene ID: (Human) 152789, (Mouse) 76071
