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Invitrogen
JMJD3 Polyclonal Antibody
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图: 1 / 3
JMJD3 Antibody (PA5-32192) in IHC (P)
JMJD3 Polyclonal Antibody detects JMJD3 protein at nucleus by immunohistochemical analysis. Sample: Paraffin-embedded rat lymph node. JMJD3 stained by JMJD3 Polyclonal Antibody (Product # PA5-32192) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-32192
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human JMJD3. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.95 mg/mL
规格
95 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A375.
Predicted reactivity: Mouse (98%), Rat (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: [histone H3]-trimethyl-L-lysine(27) demethylase 6B; JmjC domain-containing protein 3; jumonji domain containing 3; jumonji domain-containing 3; Jumonji domain-containing protein 3; Lysine demethylase 6B; Lysine-specific demethylase 6B
基因别名: 1700064E03Rik; BC038313; JMJD3; KDM6B; KIAA0346; mKIAA0346
UniProt ID: (Mouse) Q5NCY0
Entrez Gene ID: (Mouse) 216850, (Rat) 363630
sulfonate dioxygenase activity
chromatin binding
beta-catenin binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
sequence-specific DNA binding
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
histone demethylase activity (H3-K27 specific)
chromatin/chromatin-binding, or -regulatory protein
inflammatory response
chromatin modification
histone demethylation
hippocampus development
endothelial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mesodermal cell differentiation
cardiac muscle cell differentiation
oxidation-reduction process
cellular response to hydrogen peroxide
histone H3-K27 demethylation
inflammatory response to antigenic stimulus
response to activity
response to fungicide
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