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Invitrogen
JMY Polyclonal Antibody
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图: 1 / 3
JMY Antibody (PA5-106460) in WB
Western blot analysis of JMY in extracts from various samples. Samples were incubated with JMY polyclonal antibody (Product # PA5-106460). Lane 1: Mouse brain, blocked with antigen-specific peptides; Lane 2: Mouse brain; Lane 3: Rat brain; Lane 4: Mouse kidney; Lane 5: A549 cells (heat shock treatment).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-106460
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human JMY(Accession Q8N9B5), corresponding to amino acid residues E945-N988.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total JMY.
靶标信息
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ37870; Junction-mediating and -regulatory protein; p300 transcriptional cofactor JMY; similar to junction-mediating and regulatory protein
基因别名: JMY
UniProt ID: (Mouse) Q9QXM1
Entrez Gene ID: (Mouse) 57748, (Rat) 683593
DNA repair
regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
cell cycle arrest
Arp2/3 complex-mediated actin nucleation
positive regulation of apoptotic process
regulation of DNA-templated transcription in response to stress
positive regulation of sequence-specific DNA binding transcription factor activity
'de novo' actin filament nucleation
actin polymerization-dependent cell motility
intrinsic apoptotic signaling pathway by p53 class mediator
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