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Invitrogen
K-Ras Polyclonal Antibody
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K-Ras Antibody (PA5-34640) in ICC/IF
Immunofluorescent analysis of K-Ras showing staining in the cytoplasm and nucleus of HeLa cells. HeLa cells were fixed in ice-cold MeOH for 5 min and stained using a K-Ras polyclonal antibody (Product # PA5-34640) diluted at 1:500. Blue: Hoechst 33342 staining.
产品信息
PA5-34640
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment contains a sequence corresponding to a region within amino acids 4 and 164 of K-Ras
偶联物
形式
Liquid
浓度
2 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
IHC notes, Requires antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)
靶标信息
K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. It plays an important role in the regulation of cell proliferation and has a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner. Mutations in the gene can result in leukemia acute myelogenous, leukemia juvenile myelomonocytic, Noonan Syndrome, gastric cancer, and cardiofaciocutaneous syndrome 2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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