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Invitrogen
K-Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL2640)
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K-Ras (G12D Mutant) Antibody (MA5-56855) in ICC/IF
Immunocytochemistry analysis of K-Ras (G12D Mutant) using K-Ras (G12D Mutant) Recombinant Monoclonal Antibody (Product # MA5-56855) in Aspc-1 cells fixed in 4% paraformaldehyde at RT for 15 min. K-Ras (G12D Mutant) antibody diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody (Product # MA5-31466) Blue: Fluoroshield with DAPI.
产品信息
MA5-56855
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2640
抗原
Synthetic peptide of human RAS (G12D Mutant)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The K-Ras gene, specifically the G12D mutation, is a well-known oncogene implicated in various types of cancer, including pancreatic, colorectal, and lung cancers. The G12D mutation involves a substitution of glycine (G) with aspartic acid (D) at the 12th position of the K-Ras protein. This mutation leads to a constitutively active K-Ras protein that continuously signals for cell growth and division, bypassing normal regulatory mechanisms. As a result, cells harboring this mutation proliferate uncontrollably, contributing to tumorigenesis. The K-Ras (G12D) mutant is a critical target for cancer research and drug development, as targeting this mutation could potentially inhibit the aberrant signaling pathways and slow down or stop cancer progression. Despite the challenges in targeting mutant K-Ras proteins due to their high affinity for GTP/GDP and lack of suitable binding pockets, ongoing research is focused on developing specific inhibitors and novel therapeutic strategies to effectively target this mutation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; GTPase KRas; K RAS; K-Ras; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma viral oncogene homolog; KRAS; oncogene KRAS2; PR310 c-K-ras oncogene; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
基因别名: C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; KRAS1; KRAS2; NS; NS3; RALD; RASK2
UniProt ID: (Human) P01116
Entrez Gene ID: (Human) 3845
MAPK cascade
positive regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
positive regulation of cell proliferation
visual learning
positive regulation of gene expression
cytokine-mediated signaling pathway
forebrain astrocyte development
actin cytoskeleton organization
regulation of protein stability
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
social behavior
endocrine signaling
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
positive regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
homeostasis of number of cells within a tissue
leukocyte migration
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
striated muscle cell differentiation
response to glucocorticoid
response to mineralocorticoid
epithelial tube branching involved in lung morphogenesis
