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产品信息
PA5-34533
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide near the amino terminus of human KANK1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551885
产品详细信息
A suggested positive control is NIH-3T3 cell lysate.^M
^M
PA5-34533 can be used with blocking peptide PEP-1576.
靶标信息
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat domain 15; Ankyrin repeat domain-containing protein 15; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; KN motif and ankyrin repeat domains 1
基因别名: A930031B09Rik; ANKRD15; AU015049; AW121052; CPSQ2; D330024H06Rik; KANK; KANK1; KIAA0172; mKIAA0172
UniProt ID: (Human) Q14678, (Mouse) E9Q238
Entrez Gene ID: (Human) 23189, (Mouse) 107351
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of neuron projection development
positive regulation of Wnt signaling pathway
negative regulation of cell migration
negative regulation of actin filament polymerization
negative regulation of Rho protein signal transduction
positive regulation of catenin import into nucleus
negative regulation of insulin receptor signaling pathway
positive regulation of wound healing
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
regulation of establishment of cell polarity
negative regulation of lamellipodium morphogenesis
