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Invitrogen
KANK1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-52159
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: INVCGVRKRS YSAGNASQLE QLSRARRSGG ELYIDYEEEE METVEQSTQR IKEFRQLTAD MQALEQKIQD SSCEASSELR ENGECRSVAV GAEENMNDIV VYHRGSRSCK DAAVGTLVEM RNCGVSVTEA MLGVMTEADK EIE
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 81%.
靶标信息
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK1 (KN motif and ankyrin repeat domain-containing protein 1), also known as ANKRD15, is a 1,352 amino acid protein that contains at least 12 exons and 5 ANK repeats. It binds to beta-catenin and regulates its subcellular distribution. KANK1 is ubiquitously expressed and localizes to cytoplasm. It may function as a tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat domain-containing protein 15; KIAA0172; kidney ankyrin repeat-containing protein; unnamed protein product
基因别名: ANKRD15; CPSQ2; KANK
UniProt ID: (Human) Q14678
Entrez Gene ID: (Human) 23189
establishment or maintenance of cell polarity
cell proliferation
negative regulation of neuron projection development
actin cytoskeleton organization
positive regulation of Wnt signaling pathway
negative regulation of cell migration
negative regulation of actin filament polymerization
regulation of Rho protein signal transduction
negative regulation of Rho protein signal transduction
cortical microtubule organization
negative regulation of insulin receptor signaling pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of wound healing
glomerular visceral epithelial cell migration
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of ruffle assembly
regulation of establishment of cell polarity
negative regulation of lamellipodium morphogenesis
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
