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产品信息
PA5-100585
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human KANK2(Accession Q63ZY3), corresponding to amino acid residues P77-T127.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850093
产品详细信息
Antibody detects endogenous levels of total KANK2.
靶标信息
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat domain 25; Ankyrin repeat domain-containing protein 25; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; Matrix-remodeling-associated protein 3; SIP; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein
基因别名: AI504612; ANKRD25; BC010245; KANK2; KIAA1518; MXRA3; PPKWH; RGD1563532; SIP
UniProt ID: (Human) Q63ZY3, (Rat) D3ZD05, (Mouse) Q8BX02
Entrez Gene ID: (Human) 25959, (Rat) 100361376, (Mouse) 235041
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
negative regulation of cell proliferation
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of programmed cell death
negative regulation of vitamin D receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
regulation of transcription, DNA-templated
negative regulation of stress fiber assembly
