Synthetic peptide sequence: AKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKA.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH1 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH1 is activated at the onset of myoblast differentiation. KCNH1 is highly expressed in brain and in myoblasts. Overexpression of KCNH1 may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of KCNH1 results in two transcript variants encoding distinct isoforms.
蛋白别名: EAG channel 1; EAG1; ether a go-go; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; potassium channel, voltage gated eag related subfamily H, member 1; Potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; Voltage-gated potassium channel subunit Kv10.1
基因别名: EAG; EAG1; h-eag; hEAG1; KCNH1; Kv10.1; M-eag; TMBTS; ZLS1
分子生物学功能: ion channel