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Invitrogen
KCNK2 Polyclonal Antibody
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KCNK2 Antibody (PA5-111815) in IHC (F)
Immunohistochemistry analysis of KCNK2 in perfusion-fixed, frozen rat midbrain tissue sections using KCNK2 Antibody (Product # PA5-111815) at a dilution of 1:400, followed by goat-anti-guinea pig-Cy3 antibody. TREK-1 staining (red) appears in neurons in the rat lateral substantia nigra (arrows). Nuclei are stained with DAPI (blue).
产品信息
PA5-111815
产品规格
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to residues 8-25 of human KCNK2 (Intracellular, N-terminus)
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: DPKSAAQNSK PRLSFSTK(C )
Homology: Rat amino acid residues identical; mouse - 17/18 amino acidresidues identical.
靶标信息
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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