Search
Abnova
KCNN4 Polyclonal Antibody, MaxPab™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00003783-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KCNN4 (NP_002241.1, 1 a.a. approximately 427 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSWALYLFL VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL TGRQAAQIVL ELVVCGLHPA PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA LLSLAMLLRL YLVPRAVLLR SGVLLNASYR SIGALNQVRF RHWFVAKLYM NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT LWLIPITFLT IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA FRQVRLKHRK LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA GKLDALTELL STALGPRQLP EPSQQSK
靶标信息
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: gardos channel; HIK1; IKCa; intermediate conductance calcium-activated potassium channel; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; KCNN 4; KCNN4; mKCa4; KCNN4; Mutations: 960:OK; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; putative Gardos channel; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4; unnamed protein product
基因别名: DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; mIK1; mIKCa1; mKCa4; SK4; SKCa4; SKCas
UniProt ID: (Human) O15554, (Mouse) O89109
Entrez Gene ID: (Human) 3783, (Mouse) 16534
potassium channel activity
protein binding
calmodulin binding
calcium-activated potassium channel activity
small conductance calcium-activated potassium channel activity
protein phosphatase binding
Intermediate conductance calcium-activated potassium channel activity
protein homodimerization activity
inward rectifier potassium channel activity
regulation of angiotensin levels in blood
cardiac muscle hypertrophy
potassium ion transport
calcium ion transport
anion transport
cell volume homeostasis
negative regulation of cardiac muscle hypertrophy
stabilization of membrane potential
regulation of tumor necrosis factor production
macropinocytosis
phospholipid translocation
negative regulation of cell volume
saliva secretion
regulation of smooth muscle cell proliferation
positive regulation of smooth muscle cell proliferation
regulation of protein secretion
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
protein homotetramerization
positive regulation of G0 to G1 transition
regulation of monocyte chemotactic protein-1 production
mononuclear cell migration
potassium ion transmembrane transport
hepatocyte apoptotic process
potassium ion export across plasma membrane
regulation of renin secretion into blood stream
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
positive regulation of microglial cell activation
positive regulation of vascular smooth muscle cell proliferation
vascular associated smooth muscle cell migration
positive regulation of vascular associated smooth muscle cell migration
negative regulation of hepatic stellate cell proliferation
regulation of calcium ion import across plasma membrane
defense response
regulation of transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
