Search Thermo Fisher Scientific
图: 1 / 2
Antibody detects endogenous levels of total KCNQ5.
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: KQT-like 5; KvLQT5; potassium channel protein; Potassium channel subunit alpha KvLQT5; potassium channel, voltage gated KQT-like subfamily Q, member 5; Potassium voltage-gated channel subfamily KQT member 5; rCG_43583; Voltage-gated potassium channel subunit Kv7.5; voltage-gated potassium channel type Kv7.5
基因别名: 7730402H11; 9230107O05Rik; AA589396; D1Mgi1; KCNQ5; Kv7.5
UniProt ID: (Human) Q9NR82, (Mouse) Q9JK45
Entrez Gene ID: (Human) 56479, (Mouse) 226922