Immunogen sequence: GIYRTESQKL TTSESQISIS VEEWEDTKDS KEQGHHRSNH RNSTSSDQSD HPLLRR
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Kcnt2 calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. KCa channels are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance). Kcnt2 is an outward rectifying potassium channel, and produces rapidly activating outward rectifier K(+) currents. Kcnt2 is activated by high intracellular sodium and chloride levels. Further, Kcnt2 channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. Functionally, Kcnt2 is inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1.
蛋白别名: Potassium channel subfamily T member 2; potassium channel, sodium activated subfamily T, member 2; potassium channel, subfamily T, member 2; Sequence like an intermediate conductance potassium channel subunit; Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1; sodium-and chloride-activated ATP-sensitive potassium channel (SLICK)
基因别名: KCa4.2; KCNT2; SLICK; SLO2.1
UniProt ID: (Human) Q6UVM3
Entrez Gene ID: (Human) 343450
分子生物学功能: ion channel