Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Abnova
KCTD4 Polyclonal Antibody, MaxPab™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
H00386618-B01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KCTD4 (NP_940686.1, 1 a.a. approximately 259 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL DGFPEEFSIS SNIIRFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT SLDCSKGSIV HSDALHFIK
靶标信息
The KCTD4 (Potassium Channel Tetramerization Domain Containing 4) gene encodes a protein involved in various cellular processes, including the regulation of calcium homeostasis and modulation of fibroblast activity. KCTD4 interacts with chloride intracellular channel 1 (CLIC1) to disrupt calcium homeostasis, leading to increased fibronectin secretion, which activates fibroblasts via paracrine signaling. This activation can promote cancer cell invasion through matrix metalloproteinase 24 (MMP24) signaling. The interaction between KCTD4 and CLIC1 presents a potential target for therapeutic strategies, as inhibition of this interaction has been shown to significantly suppress cancer metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: BTB/POZ domain-containing protein KCTD4; potassium channel tetramerisation domain containing 4
基因别名: 2210017A09Rik; AU017169; bA321C24.3; KCTD4
UniProt ID: (Human) Q8WVF5, (Mouse) Q9D7X1
Entrez Gene ID: (Human) 386618, (Mouse) 67516
