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Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (97%), Dog (99%), Chicken (95%), Rhesus Monkey (99%), Bovine (99%).
Positive Control: 293T, A431, Raji, mouse brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP2; KChlP2; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; Potassium channel-interacting protein 2
基因别名: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61, (Mouse) Q9JJ69
Entrez Gene ID: (Human) 30819, (Mouse) 80906