Rockland

KDEL Receptor Monoclonal Antibody (KR-10)

查看其他19个KDEL抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

500-301-F86

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化 (IHC)

Assay-dependent
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Bovine, Dog, Chicken, Fruit fly, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat, Xenopus

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

KR-10

抗原

KDEL Receptor Antibody was produced in mice by repeated immunizations raised against a 21 residue synthetic peptide based on the bovine KDEL receptor and the synthetic peptide coupled to KLH.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.09% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins, GRP78 and GRP94 respectively, and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: 108K heat shock protein; 108K HSP; 78 kDa glucose-regulated protein; 78-kD glucose-regulated protein precursor; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250|UniProtKB:P08113}; 98 kDa protein kinase; Binding-immunoglobulin protein; BiP; BiP protein; CG5183-PA; CG5183-PB; CG5183-PC; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250|UniProtKB:P08113}; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein retaining receptor 1; ER lumen protein retaining receptor 2; ER lumen protein-retaining receptor; ER lumen protein-retaining receptor 1; ERp99; glucose regulated protein, 78 kDa; glucose-regulated protein; glucose-regulated protein GRP94; glucose-regulated protein, 78kDa; gp96 homolog; GRP 78; GRP-78; GRP-94; GRP94; Heat shock 108 kDa protein; heat shock 70 kDa protein 5; heat shock 70 kDa protein 5a; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 108; heat shock protein 108.; heat shock protein 5; Heat shock protein 70 family protein 5; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250|UniProtKB:P08113}; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta, member 1; Heat shock protein family A member 5; Heat shock protein family C member 4; heavy-chain binding protein BiP; HSP 108; hsp108; hsp70; HSP70 family protein 5; HSP90 beta; hsp90b1 {ECO:0000250|UniProtKB:P08113}; immunoglobulin binding protein; Immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL receptor 1; KDEL receptor-like protein; KDEL-receptor; KdelR-PA; KdelR-PB; KdelR-PC; lethal (2) 31Em; Lys-Asp-Glu-Leu; Polymorphic tumor rejection antigen 1; PPK 98; Putative MAPK-activating protein PM23; RP23-446N16.1; Steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96; XAP-1 antigen

查看更多 收起

基因别名: 8030486F04Rik; AL022860; AU019543; AW215843; baffled; BEST:CK00230; BIP; BiP/Grp78; CG5183; CK00230; D2Wsu141e; D2Wsu17e; Dmel\CG5183; Dmel_CG5183; dmErd2; ECGP; endoplasmin; ERD2; ERD2.1; ERp99; GP96; GRP78; GRP94; HDEL; HEL-S-125m; HEL-S-89n; HEL35; Hsce70; hsp108; HSP90B1; HSPA5; hspa5a; HSPC4; I79_019946; I79_020931; KDELR; KDELR1; l(2)31Em; l(2)k00311; mBiP; MIF2; PM23; ppk98; SEZ-7; Sez7; TA-3; Targ2; Tra-1; TRA1; XAP-1; XELAEV_180384511mg

查看更多 收起

UniProt ID: (Pig) Q29092, (Dog) P41148, (Bovine) Q95M18, (Chicken) P08110, (Human) P14625, (Chicken) Q90593, (Bovine) Q0VCX2, (Human) P11021, (Rat) Q66HD0, (Mouse) P08113, (Mouse) P20029, (Chinese hamster) G3I8R9, (Rat) P06761, (Bovine) P33946, (Human) P24390, (Fruit fly) O76767, (Mouse) Q99JH8, (Rat) Q569A6, (Xenopus) Q91883

查看更多 收起

Entrez Gene ID: (Pig) 397191, (Rabbit) 100009456, (Dog) 404019, (Bovine) 282646, (Chicken) 374163, (Human) 7184, (Sheep) 101111703, (Chicken) 396487, (Sheep) 780447, (Dog) 480726, (Pig) 407060, (Rabbit) 100008764, (Bovine) 415113, (Human) 3309, (Chinese hamster) 100773331, (Rat) 362862, (Mouse) 22027, (Mouse) 14828, (Chinese hamster) 100689305, (Rat) 25617, (Pig) 100520962, (Bovine) 618184, (Sheep) 101122047, (Human) 10945, (Dog) 484406, (Rabbit) 100349892, (Fruit fly) 34427, (Chinese hamster) 100750912, (Mouse) 68137, (Rat) 361577, (Xenopus) 397850

查看更多 收起

功能
ATP binding RNA binding protein phosphatase binding low-density lipoprotein particle receptor binding unfolded protein binding calcium ion binding protein binding virion binding ATPase activity heat shock protein binding protein binding involved in protein folding misfolded protein binding protein domain specific binding ubiquitin protein ligase binding ribosome binding glycoprotein binding enzyme binding chaperone binding cadherin binding involved in cell-cell adhesion nucleotide binding KDEL sequence binding ER retention sequence binding molecular_function Hsp90 family chaperone membrane trafficking regulatory protein
参与通路
ER-associated ubiquitin-dependent protein catabolic process response to hypoxia retrograde protein transport, ER to cytosol actin rod assembly negative regulation of apoptotic process regulation of phosphoprotein phosphatase activity cellular response to ATP protein folding intracellular sequestering of iron ion toll-like receptor signaling pathway receptor-mediated endocytosis protein transport protein folding in endoplasmic reticulum response to endoplasmic reticulum stress ATF6-mediated unfolded protein response sequestering of calcium ion response to unfolded protein endoplasmic reticulum unfolded protein response negative regulation of protein complex assembly cellular response to unfolded protein protein refolding chaperone mediated protein folding requiring cofactor negative regulation of IRE1-mediated unfolded protein response positive regulation of cell migration posttranslational protein targeting to membrane, translocation maintenance of protein localization in endoplasmic reticulum ER overload response cerebellum structural organization cerebellar Purkinje cell layer development negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein ubiquitination cellular response to glucose starvation cellular response to interleukin-4 toxin transport activation of signaling protein activity involved in unfolded protein response substantia nigra development IRE1-mediated unfolded protein response PERK-mediated unfolded protein response regulation of protein folding in endoplasmic reticulum cellular response to antibiotic cellular response to manganese ion negative regulation of protein homodimerization activity cell-cell adhesion regulation of ATF6-mediated unfolded protein response regulation of IRE1-mediated unfolded protein response regulation of PERK-mediated unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress response to stress positive regulation of embryonic development proteolysis involved in cellular protein catabolic process T cell cytokine production retrograde vesicle-mediated transport, Golgi to ER T cell differentiation T cell apoptotic process protein retention in ER lumen intracellular protein transport ER to Golgi vesicle-mediated transport transport biological_process vesicle-mediated transport
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持