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Proteintech
KIAA0141 Polyclonal Antibody
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产品信息
21904-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KIAA0141 Fusion Protein Ag14615 (164-515 aa encoded by BC007855)
偶联物
形式
Liquid
浓度
0.36 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: QEEASAQPR NFSHNSLRGA RPQDPSEEGP GDFGFLHASS SIESEAKPAQ PQPTGEKEQD KSKTLSLEEA VTSIQQLFQL SVSITFNFLG TENMKSGDHT AAFSYFQKAA ARGYSKAQYN AGLCHEHGRG TPRDISKAVL YYQLAASQGH SLAQYRYARC LLRDPASSWN PERQRAVSLL KQAADSGLRE AQAFLGVLFT KEPYLDEQRA VKYLWLAANN GDSQSRYHLG ICYEKGLGVQ RNLGEALRCY QQSAALGNEA AQERLRALFS MGAAAPGPSD LTVTGLKSFS SPSLCSLNTL LAGTSRLPHA SSTGNLGLLC RSGHLGASLE ASSRAIPPHP YPLERSVVRL GFG (164-515 aa encoded by BC007855)
靶标信息
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1, long form; Death ligand signal enhancer; DELE1(L)
基因别名: 2700004E22Rik; DELE; DELE1; KIAA0141
UniProt ID: (Mouse) Q9DCV6, (Human) Q14154
Entrez Gene ID: (Mouse) 66839, (Human) 9812
