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Abnova
KIAA0157 Polyclonal Antibody, MaxPab™
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产品信息
H00023172-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KIAA0157 (NP_115558.2, 1 a.a. approximately 311 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSYREQVLHK QLTRILGVPD LVFLLFSFIS TANNSTHALE YVLFRPNRRY NQRISLAIPN LGNTSQQEYK VSSVPNTSQS YAKVIKEHGT DFFDKDGVMK DIRAIYQVYN ALQEKVQAVC ADVEKSERVV ESCQAEVNKL RRQITQRKNE KEQERRLQQA VLSRQMPSES LDPAFSPRMP SSGFAAEGRS TLGDAEASDP PPPYSDFHPN NQESTLSHSR MERSVFMPRP QAVGSSNYAS TSAGLKYPGS GADLPPPQRA AGDSGEDSDD SDYENLIDPT EPSNSEYSHS KDSRPMAHPD EDPRNTQTSQ I
靶标信息
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Abraxas brother; abraxas brother 1; Abraxas brother protein 1; BRISC complex subunit Abraxas 2; Em:AC068896.4; family with sequence similarity 175, member B; Protein FAM175B
基因别名: ABRAXAS2; ABRO1; FAM175B; KIAA0157
UniProt ID: (Human) Q15018
Entrez Gene ID: (Human) 23172
