Invitrogen

KIAA1429 Polyclonal Antibody

KIAA1429 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 7

KIAA1429 Antibody (PA5-95717) in IHC (P)

Immunohistochemistry analysis of KIAA1429 in paraffin-embedded human esophageal cancer. Samples were incubated with KIAA1429 Polyclonal antibody (Product # PA5-95717) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Product Image Gallery

产品信息

PA5-95717

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:100

免疫细胞化学 (ICC/IF)

1:50-1:100

RNA免疫共沉淀 (RIP)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human KIAA1429 (NP_0563112)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.08 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2807519

产品详细信息

Immunogen sequence: FMRQILNSDT IGCCGDDNGL MEVEGAHTSR TMSINAAELK QLLQSKEESP ENLFLELEKL VLEHSKDDDN LDSLLDSVVG LKQMLESSGD PLPLSDQDVE PVLSAPESLQ NLFNNRTAYV LADVMDDQLK SMWFTPFQAE EIDTDLDLVK VDLIELSEKC CSDFDLHSEL ERSFLSEPSS PGRTKTTKGF KLGKHKHETF ITSSGKSEYI EPAKRAHVVP PPRGRGRGGF GQGIRPHDIF RQRKQNTSRP PSMHVDDFVA AESKEVVPQD GIPPPKRPLK VSQKISSRGG FSGNRGGRGA F; Positive Samples: K-562, COS7, HeLa, PC-3

靶标信息

KIAA1429 is required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing. It is also Involved in mRNA splicing regulation, probably via its function in m6A methylation. Diseases associated with KIAA1429 include Retinitis Pigmentosa 42.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

m⁶A Methyltransferase KIAA1429 Regulates the Cisplatin Sensitivity of Gastric Cancer Cells via Stabilizing FOXM1 mRNA.

Cancers

Zhu Z,Zhou Y,Chen Y,Zhou Z,Liu W,Zheng L,Pei Q,Tan F,Pei H,Li Y

Published figure using KIAA1429 polyclonal antibody (Product # PA5-95717) in Western Blot

Fri Oct 14 00:00:00 EDT 2022

m⁶A methyltransferase KIAA1429 acts as an oncogenic factor in colorectal cancer by regulating SIRT1 in an m⁶A-dependent manner.

Cell death discovery

Zhou Y,Pei Z,Maimaiti A,Zheng L,Zhu Z,Tian M,Zhou Z,Tan F,Pei Q,Li Y,Liu W

PA5-95717 was used in RNA Immunoprecipitation to suggest that the m6A methyltransferase KIAA1429 promotes the growth and motility of colorectal cancer and could be a potent therapeutic target.