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Invitrogen
KIF2A Polyclonal Antibody
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KIF2A Antibody (PA5-95751) in WB
Western blot analysis of KIF2A in extracts of various cell lines. Samples were incubated with KIF2A Polyclonal antibody (Product # PA5-95751) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-95751
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 30-220 of human KIF2A (NP_0045112)
偶联物
形式
Liquid
浓度
0.59 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TSLNEDNESV TVEWIENGDT KGKEIDLESI FSLNPDLVPD EEIEPSPETP PPPASSAKVN KIVKNRRTVA SIKNDPPSRD NRVVGSARAR PSQFPEQSSS AQQNGSVSDI SPVQAAKKEF GPPSRRKSNC VKEVEKLQEK REKRRLQQQE LREKRAQDVD ATNPNYEIMC MIRDFRGSLD YRPLTTADPI D; Positive Samples: Rat brain; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole
靶标信息
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hK2; kif2a {ECO:0000250|UniProtKB:O00139}; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A
基因别名: C530030B14Rik; CDCBM3; HK2; KIF2; KIF2A; KNS2; M-kinesin
UniProt ID: (Human) O00139, (Mouse) P28740
Entrez Gene ID: (Human) 3796, (Rat) 84391, (Mouse) 16563
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
mitotic spindle organization
sister chromatid cohesion
nervous system development
antigen processing and presentation of exogenous peptide antigen via MHC class II
cell differentiation
cell division
mitotic spindle assembly
microtubule depolymerization
metabolic process
cell cycle
mitotic nuclear division
multicellular organism development
