The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
KIR3DL1 are Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. 4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
蛋白别名: 3DL1; AMB11; CD158 antigen-like family member E; CD158e; CD158e antigen; CD158E1/2; CD158E2; HLA-BW4-specific inhibitory NK cell receptor; Killer cell immunoglobulin-like receptor 3DL1; killer cell immunoglobulin-like receptor Kir3dl1; killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 2; killer cell immunoglobulin-like receptor three domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; killer Ig receptor; killer immunoglobulin receptor-like protein 1; KIR antigen 3DL1; KIR G1; KIR-like receptor 1; KIR3D; KIR3DS1; MGC119726; MGC119728; MGC126589; MGC126591; MHC class I NK cell receptor; natural killer cell receptor; Natural killer-associated transcript 3; NK receptor; NK-receptor; NKAT-3; NKAT10; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK; p70 NK receptor CL-2/CL-11
基因别名: CD158E; CD158E1; KIR; KIR3DL1; KIR3DL1/S1; KIR3DL2; Kirl1; Kirl2; Krl1; NKAT-3; NKAT3; NKB1; NKB1B
UniProt ID: (Human) P43629
分子生物学功能: immunoglobulin receptor superfamily