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KLF 1, 2, 4, 5, 7, 12 Polyclonal Antibody

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持
KLF 1, 2, 4, 5, 7, 12 Polyclonal Antibody

产品信息

OSK00001W-100UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:300-1:2,000
-

免疫组化 (IHC)

1:300-1:2,000
-

其他PubMed (Misc)

-
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产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / Ig

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide from the c-terminal of human Krueppel-like factor 1, 2, 4, 5, 7, 12 (KLF1, KLF2, KLF4, KLF5, KLF7, KLF12) conjugated to blue carrier protein was used as the antigen
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in many species including rat, mouse.

Specificity of this antibody: Krueppel-like factor 1, 2, 4, 5, 7, 12 (KLF1, KLF2, KLF4, KLF5, KLF7, KLF12).

靶标信息

The Kruppel family of transcription factors (KLFs) are a set of C2H2-type zinc-finger DNA binding proteins that regulate gene expression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: (intestinal Kruppel-like factor; AP-2 repressor; AP-2rep transcription factor; basic transcription element binding protein 2; basic transcription element binding protein BTEB2; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; colon kruppel-like factor; EKLF; endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid transcription factor; erythroid-specific transcription factor EKLF; GC box binding protein 2; GC-box-binding protein 2; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; KLF12 zinc finger transcriptional repressor; Klf5C isoform; Krueppel-like factor 1; Krueppel-like factor 12; Krueppel-like factor 2; Krueppel-like factor 4; Krueppel-like factor 5; Krueppel-like factor 7; Kruppel-like factor 1 (erythroid); Kruppel-like factor 12; Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor 5 (intestinal); Kruppel-like factor 7 (ubiquitous); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor; monoclonal antibody A3D8; neonatal anemia; Transcription factor BTEB2; Transcriptional repressor AP-2rep; truncated EKLF; truncated erythroid Kruppel-like factor 1; Ubiquitous krueppel-like factor; ubiquitous Kruppel-like factor; ubiquitous Kruppel-like transcription factor

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基因别名: 2700063E05Rik; 4930520J07Rik; 9830124P08Rik; AI225908; AI315654; AP-2rep; AP2REP; B130052C06Rik; BTEB2; CDAN4; CKLF; D530033K05Rik; EKLF; EZF; GKLF; HBFQTL6; HSPC122; IKLF; INLU; KLF1; KLF12; KLF2; KLF4; KLF5; KLF7; LKLF; Nan; UKLF; Zie

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UniProt ID: (Human) Q13351, (Human) Q9Y4X4, (Human) Q9Y5W3, (Human) O43474, (Human) Q13887, (Human) O75840, (Mouse) O35738, (Mouse) Q60843, (Rat) Q9ET58, (Mouse) Q60793, (Mouse) Q9Z0Z7, (Mouse) Q99JB0

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Entrez Gene ID: (Human) 10661, (Human) 11278, (Human) 10365, (Human) 9314, (Human) 688, (Human) 8609, (Mouse) 16596, (Rat) 304666, (Mouse) 16597, (Rat) 306110, (Mouse) 16598, (Rat) 306330, (Mouse) 16600, (Rat) 114505, (Rat) 84410, (Mouse) 12224, (Mouse) 93691, (Rat) 363243

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功能
core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding metal ion binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription corepressor activity protein binding sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription cofactor binding beta-catenin binding zinc ion binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription coactivator activity nucleic acid binding protein domain specific binding activating transcription factor binding double-stranded DNA binding transcription factor binding C2H2 zinc finger transcription factor
参与通路
transcription, DNA-templated regulation of transcription, DNA-templated erythrocyte differentiation positive regulation of transcription, DNA-templated cellular response to peptide negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter cell morphogenesis in utero embryonic development negative regulation of interleukin-6 production multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic erythrocyte maturation positive regulation of nitric oxide biosynthetic process positive regulation of protein metabolic process Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to cycloheximide cellular response to laminar fluid shear stress transcription from RNA polymerase II promoter mesodermal cell fate determination negative regulation of cell proliferation epidermal cell differentiation positive regulation of gene expression negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia stem cell population maintenance post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process negative regulation of heterotypic cell-cell adhesion somatic stem cell population maintenance post-embryonic hemopoiesis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of interleukin-8 biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis negative regulation of inflammatory response negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus negative regulation of cell migration involved in sprouting angiogenesis negative regulation of leukocyte adhesion to arterial endothelial cell negative regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of transcription regulatory region DNA binding angiogenesis microvillus assembly regulation of microvillus assembly skeletal muscle cell differentiation positive regulation of fat cell differentiation intestinal epithelial cell development axon guidance dendrite morphogenesis liver development chromatin remodeling embryonic hemopoiesis erythrocyte development erythrocyte homeostasis response to laminar fluid shear stress cellular response to organic cyclic compound response to organic substance cell differentiation response to retinoic acid regulation of cell proliferation positive regulation of cell proliferation axonogenesis
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