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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:50-1:100 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthetic peptide derived from the internal region of human KLF10/11 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2555269 |
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: early growth response-alpha; EGR-alpha; GDNF-inducible factor; klf11; Krueppel-like factor 10; Krueppel-like factor 11; Kruppel-like factor 10; Kruppel-like factor 11; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB inducible early growth response 2; TGFB inducible early growth response 3; TGFB-inducible early growth response protein 1; TGFB-inducible early growth response protein 2; TGFB-inducible early growth response protein 2b; TGFB-inducible early growth response protein 3; TIEG-1; TIEG-2; TIEG-3; transcription factor CP2-like 2; Transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; Transforming growth factor-beta-inducible early growth response protein 2; Transforming growth factor-beta-inducible early growth response protein 3; Zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
基因别名: 9830142A17; AI115143; Cpg20; D12Ertd427e; EGR-alpha; EGR[a]; EGRA; Egral; FKLF; FKLF1; Gdnfif; KLF10; KLF11; mGIF; MODY7; Tcfcp2l2; TIEG; TIEG-1; TIEG1; TIEG2; Tieg2b; Tieg3
UniProt ID: (Human) Q13118, (Human) O14901, (Rat) O08876, (Mouse) O89091, (Mouse) Q8K1S5
Entrez Gene ID: (Human) 7071, (Human) 8462, (Rat) 81813, (Mouse) 21847, (Rat) 313994, (Mouse) 194655
