FIGURE: 1 / 1
Peptide Sequence: MNIHMKRKTI KNINTFENRM LMLDGMPAVR VKTELLESEQ GSPNVHNYPD MEAVPLLLNN VKGEPPEDSL SVDHFQTQTE PVDLSINKAR
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
Protein Aliases: AP-2 repressor; AP-2rep transcription factor; BHLHB24; ID; KLF12 zinc finger transcriptional repressor; Krueppel-like factor 12; Kruppel-like factor 12; Transcriptional repressor AP-2rep
Gene Aliases: AP-2rep; AP2REP; HSPC122; KLF12
UniProt ID: (Human) Q9Y4X4
Entrez Gene ID: (Human) 11278
Molecular Function: C2H2 zinc finger transcription factor