Bioss

KLF2/4 Polyclonal Antibody

问题与答案

问题与答案

问题与答案

抗体检测数据 (2)

KLF2/4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

KLF2/4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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KLF2/4 Antibody (BS-1064R) in IHC (P)

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti KLF4 Polyclonal Antibody, Unconjugated (bs-1064R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

KLF2/4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

KLF2/4 Antibody in Western Blot (WB)

Product Image Gallery

KLF2/4 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti KLF4 Polyclonal Antibody, Unconjugated (bs-1064R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

KLF2/4 Antibody in Western Blot (WB) — L1 rat kidney lysates L2 human colon carcinoma lysates probed with Anti KLF4 Polyclonal Antibody, Unconjugated (bs-1064R) at 1:200 overnight at 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at 37°C. Predicted band 56 kD. Observed band size: 56 kD.

产品信息

BS-1064R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:200

-

免疫组化（石蜡） (IHC (P))

1:200

-

免疫组化（冰冻） (IHC (F))

1:100-1:500

-

免疫细胞化学 (ICC/IF)

1:50-1:200

-

流式细胞分析 (Flow)

1:20-1:100

-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human KLF4.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 2; Krueppel-like factor 4; Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor

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基因别名: EZF; GKLF; KLF2; KLF4; LKLF; Zie

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UniProt ID: (Human) Q9Y5W3, (Human) O43474, (Mouse) Q60843, (Rat) Q9ET58, (Mouse) Q60793

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Entrez Gene ID: (Human) 10365, (Human) 9314, (Mouse) 16598, (Rat) 306330, (Mouse) 16600, (Rat) 114505

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transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding metal ion binding core promoter proximal region sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription cofactor binding beta-catenin binding zinc ion binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding transcription regulatory region DNA binding nucleic acid binding DNA binding double-stranded DNA binding transcription factor binding C2H2 zinc finger transcription factor

cell morphogenesis in utero embryonic development transcription, DNA-templated negative regulation of interleukin-6 production multicellular organism growth positive regulation of transcription from RNA polymerase II promoter in response to stress regulation of gene expression, epigenetic erythrocyte maturation positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of protein metabolic process Type I pneumocyte differentiation cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to cycloheximide cellular response to laminar fluid shear stress cellular response to peptide negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter mesodermal cell fate determination negative regulation of cell proliferation epidermal cell differentiation positive regulation of gene expression negative regulation of gene expression negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of muscle hyperplasia stem cell population maintenance post-embryonic camera-type eye development negative regulation of NF-kappaB transcription factor activity positive regulation of cellular protein metabolic process negative regulation of heterotypic cell-cell adhesion somatic stem cell population maintenance post-embryonic hemopoiesis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of interleukin-8 biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis negative regulation of inflammatory response negative regulation of protein kinase B signaling positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of response to cytokine stimulus negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus negative regulation of cell migration involved in sprouting angiogenesis negative regulation of leukocyte adhesion to arterial endothelial cell negative regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of transcription regulatory region DNA binding regulation of transcription, DNA-templated erythrocyte homeostasis response to laminar fluid shear stress cellular response to organic cyclic compound regulation of transcription from RNA polymerase II promoter response to organic substance cell differentiation response to retinoic acid regulation of cell proliferation