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KLF4 Polyclonal Antibody

查看其他22个KLF4抗体

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KLF4 Polyclonal Antibody

产品信息

PA5149639

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL
-

免疫组化（石蜡） (IHC (P))

1:1,000-1:2,500
-

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL
-

染色质免疫沉淀 实验 (ChIP)

1-10 µg
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human KLF4
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3709627

产品详细信息

Immunogen sequence: ETEEFNDLLD LDFILSNSLT HPPESVAATV SSSASASSSS SPSSSGPASA PSTCSFTYPI RAGNDPGVAP GGTGGGLLYG RESAPPPTAP FNLADINDVS P

Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 89%.

靶标信息

Kruppel like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. It is also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF) and belongs to a family of conserved Kruppel-like factor family of DNA binding zinc finger transcription factors. KLF4 exerts its functional relevance across varied cellular pathways. As one of the four Yamanaka factors, it plays a key role in reprogramming differentiated cells into pluripotent stem cells. Most studies have focused on its specific role in endothelial cell signaling, adipogenesis, differentiation, embryogenesis and cell cycle control. Localization plays an important role in the biological significance of this protein wherein nuclear localization is associated with its function as an oncogene and cytosolic localization with tumor suppression specific effect.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 4; Kruppel like factor 4; Kruppel-like factor 4 (gut); Kruppel-like zinc finger protein; RP11-150J11.1; transcription factor; unnamed protein product

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基因别名: EZF; GKLF; KLF4

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UniProt ID: (Human) O43474

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Entrez Gene ID: (Human) 9314

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功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding transcription factor recruiting transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding zinc ion binding chromatin DNA binding phosphatidylinositol 3-kinase regulator activity histone deacetylase binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
参与通路
negative regulation of transcription from RNA polymerase II promoter defense response to tumor cell transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter mesodermal cell fate determination negative regulation of cell proliferation epidermis development epidermal cell differentiation gene expression positive regulation of gene expression negative regulation of gene expression negative regulation of muscle hyperplasia negative regulation of angiogenesis stem cell population maintenance negative regulation of cell migration epithelial cell differentiation post-embryonic camera-type eye development positive regulation of telomere maintenance response to retinoic acid negative regulation of interleukin-8 production negative regulation of heterotypic cell-cell adhesion somatic stem cell population maintenance post-embryonic hemopoiesis regulation of cell proliferation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of nitric oxide biosynthetic process fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hemoglobin biosynthetic process negative regulation of smooth muscle cell proliferation regulation of axon regeneration epidermis morphogenesis negative regulation of inflammatory response positive regulation of protein metabolic process negative regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of response to cytokine stimulus establishment of skin barrier cellular response to hydrogen peroxide negative regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to growth factor stimulus cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis regulation of blastocyst development positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of sprouting angiogenesis negative regulation of leukocyte adhesion to arterial endothelial cell cellular response to leukemia inhibitory factor cellular response to endothelin negative regulation of G1/S transition of mitotic cell cycle negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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