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Proteintech
KPNA6 Polyclonal Antibody
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产品信息
12366-2-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KPNA6 Fusion Protein Ag3040 (185-536 aa encoded by BC020520)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: EQAVWALGN IAGDSSVCRD YVLNCSILNP LLTLLTKSTR LTMTRNAVWA LSNLCRGKNP PPEFAKVSPC LPVLSRLLFS SDSDLLADAC WALSYLSDGP NEKIQAVIDS GVCRRLVELL MHNDYKVASP ALRAVGNIVT GDDIQTQVIL NCSALPCLLH LLSSPKESIR KEACWTISNI TAGNRAQIQA VIDANIFPVL IEILQKAEFR TRKEAAWAIT NATSGGTPEQ IRYLVSLGCI KPLCDLLTVM DSKIVQVALN GLENILRLGE QEGKRSGSGV NPYCGLIEEA YGLDKIEFLQ SHENQEIYQK AFDLIEHYFG VEDDDSSLAP QVDETQQQFI FQQPEAPMEG FQL (185-536 aa encoded by BC020520)
靶标信息
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: FLJ11249; importin alpha 7 subunit; Importin subunit alpha-7; importin-alpha-S2; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); Karyopherin subunit alpha-6; MGC17918; RP4-622L5.1
基因别名: IPOA7; KPNA6; KPNA7
UniProt ID: (Human) O60684
Entrez Gene ID: (Human) 23633
