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Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dickkopf receptor 2; Kremen protein 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose
基因别名: 2900054E04Rik; Kremen2; Krm2
UniProt ID: (Mouse) Q8K1S7
Entrez Gene ID: (Mouse) 73016