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Invitrogen
KRIT1 Recombinant Rabbit Monoclonal Antibody (K01_1T31)
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产品信息
MA563692
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_1T31
抗原
Recombinant protein of human KRIT1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 150mM NaCl, 40% glycerol, 0.05% BSA
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ankyrin repeat-containing protein Krit1; Cerebral cavernous malformations 1 protein; Cerebral cavernous malformations 1 protein homolog; Krev interaction trapped 1; Krev interaction trapped protein 1
基因别名: 2010007K12Rik; A630036P20Rik; AA432855; AI450393; AI643869; BB155247; BB235701; CAM; CCM1; KRIT1; RGD1305929
UniProt ID: (Human) O00522, (Mouse) Q6S5J6
Entrez Gene ID: (Human) 889, (Rat) 362317, (Mouse) 79264
angiogenesis
negative regulation of endothelial cell proliferation
small GTPase mediated signal transduction
negative regulation of endothelial cell migration
negative regulation of angiogenesis
positive regulation of protein binding
cell redox homeostasis
regulation of catalytic activity
regulation of establishment of cell polarity
negative regulation of endothelial cell apoptotic process
biological_process
