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产品信息
PA5-41032
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human KCNA10
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2607714
产品详细信息
Peptide sequence: PANVPIDIFA DEISFYELGS EAMDQFREDE GFIKDPETLL PTNDIHRQFW
Sequence homology: Cow: 100%; Dog: 92%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Rat: 100%
靶标信息
KCNA10 is a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.
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生物信息学
蛋白别名: cyclic GMP gated potassium channel; potassium channel, voltage gated shaker related subfamily A, member 10; Potassium voltage-gated channel subfamily A member 10; potassium voltage-gated channel, shaker-related subfamily, member 10; Voltage-gated potassium channel subunit Kv1.8
基因别名: Kcn1; KCNA10; Kv1.8
UniProt ID: (Human) Q16322
Entrez Gene ID: (Human) 3744
