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Invitrogen
Kininogen Heavy Chain Monoclonal Antibody (2B5)
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产品信息
MA1-10832
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2B5
抗原
Purified high molecular weight kininogen.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-10832 detects High MW Kininogen, heavy chain, from human samples.
MA1-10832 has been successfully used in ELISA and Western blot applications.
The MA1-10832 immunogen is purified high molecular weight kininogen.
靶标信息
This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-2-thiol proteinase inhibitor; bradykinin; Fitzgerald factor; High molecular weight kininogen; HMWK; Kininogen-1; Williams-Fitzgerald-Flaujeac factor
基因别名: BDK; BK; KNG; KNG1
UniProt ID: (Human) P01042
Entrez Gene ID: (Human) 3827
platelet degranulation
smooth muscle contraction
inflammatory response
negative regulation of cell adhesion
positive regulation of cytosolic calcium ion concentration
blood coagulation, intrinsic pathway
negative regulation of endopeptidase activity
negative regulation of blood coagulation
positive regulation of urine volume
positive regulation of renal sodium excretion
vasodilation
positive regulation of apoptotic process
negative regulation of proteolysis
