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Invitrogen
L-kynurenine Recombinant Mouse Monoclonal Antibody (1G1)
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L-kynurenine Antibody (MA566434) in SDS-PAGE
SDS-PAGE characterization of L-kynurenine under reducing conditions. Lane M: Protein marker (kDa); Lane L-KYN: Purified L-kynurenine Recombinant Monoclonal (Product # MA566434). L-kynurenine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-353.
产品信息
MA566434
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1G1
抗原
Conjugate of L-KYN hapten and KLH.
偶联物
形式
Liquid
浓度
7.5 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
L-kynurenine is a key intermediate in the kynurenine pathway, which is the primary route for the catabolism of the amino acid tryptophan in mammals. This pathway is responsible for over 95% of tryptophan degradation and leads to the production of several biologically active metabolites, including kynurenic acid and NAD+. L-kynurenine is synthesized from tryptophan by the enzyme tryptophan 2,3-dioxygenase and further metabolized by kynureninase, which preferentially reacts with L-kynurenine in prokaryotes and with 3-hydroxy-L-kynurenine in eukaryotes. The structure of kynureninase has been elucidated through crystallography studies, revealing the active sites in both Pseudomonas fluorescens and Homo sapiens. Functionally, L-kynurenine and its metabolites play roles in immune response, neuronal excitability, and host-microbiome signaling, with implications for inflammation and neuroprotection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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