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Proteintech
LAP2 Polyclonal Antibody
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产品信息
14651-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LAP2 Fusion Protein Ag6247 (1-362 aa encoded by BC053675)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MPEFLEDPS VLTKDKLKSE LVANNVTLPA GEQRKDVYVQ LYLQHLTARN RPPLPAGTNS KGPPDFSSDE EREPTPVLGS GAAAAGRSRA AVGRKATKKT DKPRQEDKDD LDVTELTNED LLDQLVKYGV NPGPIVGTTR KLYEKKLLKL REQGTESRSS TPLPTISSSA ENTRQNGSND SDRYSDNEED SKIELKLEKR EPLKGRAKTP VTLKQRRVEH NQSYSQAGIT ETEWTSGSSK GGPLQALTRE STRGSRRTPR KRVETSEHFR IDGPVISEST PIAETIMASS NESLVVNRVT GNFKHASPIL PITEFSDIPR RAPKKPLTRA EVGEKTEERR VERDILKEMF PYEASTPTGI SAS (1-362 aa encoded by BC053675)
靶标信息
In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B and 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A/B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoform alpha; Lamina-associated polypeptide 2, isoform beta; Lamina-associated polypeptide 2, isoforms beta/gamma; LEM domain containing 4; Thymopoietin (lamina associated polypeptide 2); thymopoietin beta; Thymopoietin isoform alpha; Thymopoietin isoform beta; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoform alpha; Thymopoietin-related peptide isoforms beta/gamma; TP alpha; TP beta; TP beta/gamma; TPRP isoform alpha; TPRP isoforms beta/gamma
基因别名: CMD1T; LAP2; LEMD4; PRO0868; TMPO; TP
UniProt ID: (Human) P42166, (Rat) Q62733
Entrez Gene ID: (Human) 7112, (Rat) 25359
