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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.2-1 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide directed towards the middle region of human LARGE |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Affinity Chromatography |
保存液 |
PBS with 2% sucrose |
内含物 |
0.09% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2609912 |
Peptide sequence: AHIMELDVQE YEFIVLPNAY MIHMPHAPSF DITKFRSNKQ YRICLKTLKE
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
The LARGE gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; Beta-1,3-glucuronyltransferase LARGE; Glycosyltransferase-like protein; LARGE xylosyl- and glucuronyltransferase 1; like-acetylglucosaminyltransferase; like-glycosyltransferase; Xylosyltransferase LARGE
基因别名: KIAA0609; LARGE; LARGE1; MDC1D; MDDGA6; MDDGB6
UniProt ID: (Human) O95461
Entrez Gene ID: (Human) 9215
分子生物学功能:
glycosyltransferase
