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Invitrogen
LAX1 Polyclonal Antibody
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LAX1 Antibody (PA5-88428) in WB
Western blot analysis of LAX1 in extracts of various cell lines. Samples were incubated with LAX1 Polyclonal antibody (Product # PA5-88428) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-88428
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_0602432)
偶联物
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MPLLTLPQTR QRAKNIYDIL PWRQEDLGRH ESRSMRIFST ESLLSRNSES PEHVPSQAGN AFQEHTAHIH ATEYAVGIYD NAMVPQMCGN LTPSAHCINV RASRDCASIS SEDSHDYVNV PTAEEIAETL ASTKSPSRNL FVLPSTQKLE FTEERDEGCG DAGDCTSLYS PGAEDSDSLS NGEGSSQISN DYVNMTGLDL SAIQERQLWV AFQCCRDYEN VPAADPSGSQ QQAEKDVPSS NIGHVEDKTD DPGTHVQCVK RTFLASGDYA DFQPFTQSED SQMKHREEMS NEDSSDYENV LTAKLGGRDS EQGPGTQLLP DE; Positive Samples: Raji, Mouse liver; Cellular Location: Cell membrane, Single-pass type III membrane protein
靶标信息
Lymphocyte activation gene 1 (LAX1) is located on chromosome 2p16.1 and encodes an immunoregulatory protein that is expressed primarily on lymphocytes, including T cells, B cells, and other immune cells. LAX1 functions as a negative regulator of lymphocyte activation and signaling, playing a crucial role in maintaining immune homeostasis by attenuating excessive immune responses. It acts by modulating signaling pathways that are initiated through surface receptors on lymphocytes, thereby influencing lymphocyte proliferation, cytokine production, and cellular responses during immune activation. Dysregulation of LAX1 expression or function can lead to autoimmune diseases due to impaired control of immune activation. Research into LAX1 focuses on its potential for therapeutic modulation in autoimmune disorders and its role in balancing immune responses, which is essential for maintaining health and preventing pathogenic immune conditions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LAT-like membrane associated protein; Linker for activation of X cells; Lymphocyte transmembrane adapter 1; Membrane-associated adapter protein LAX
基因别名: A530029E09; E430019B13Rik; LAX; LAX1
UniProt ID: (Human) Q8IWV1, (Mouse) Q8BHB3
Entrez Gene ID: (Human) 54900, (Mouse) 240754
