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Proteintech
LBP Monoclonal Antibody (3A7E3)
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产品信息
66181-1-IG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
3A7E3
抗原
LBP Fusion Protein Ag13485 (128-477 aa encoded by BC022256)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SFDVSVKGI SISVNLLLGS ESSGRPTVTA SSCSSDIADV EVDMSGDLGW LLNLFHNQIE SKFQKVLESR ICEMIQKSVS SDLQPYLQTL PVTTEIDSFA DIDYSLVEAP RATAQMLEVM FKGEIFHRNH RSPVTLLAAV MSLPEEHNKM VYFAISDYVF NTASLVYHEE GYLNFSITDD MIPPDSNIRL TTKSFRPFVP RLARLYPNMN LELQGSVPSA PLLNFSPGNL SVDPYMEIDA FVLLPSSSKE PVFRLSVATN VSATLTFNTS KITGFLKPGK VKVELKESKV GLFNAELLEA LLNYYILNTF YPKFNDKLAE GFPLPLLKRV QLYDLGLQIH KDFPSRRDHP P (128-477 aa encoded by BC022256)
靶标信息
The LBP protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BPI fold containing family D, member 2; LBP; Lipopolysaccharide-binding protein; LPS-binding protein
基因别名: BPIFD2; LBP
UniProt ID: (Human) P18428
Entrez Gene ID: (Human) 3929
liver development
leukocyte chemotaxis involved in inflammatory response
macrophage activation involved in immune response
acute-phase response
cellular defense response
opsonization
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of molecule of bacterial origin
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of macrophage activation
negative regulation of growth of symbiont in host
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of phagocytosis, engulfment
positive regulation of respiratory burst involved in inflammatory response
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
regulation of membrane permeability
