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产品信息
PA5-64884
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫细胞化学 (ICC/IF) |
0.25-2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant Human LBX1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.10 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.2, with 40% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2662958 |
产品详细信息
Immunogen sequence: ITWFQNRRAKL KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEATAG GGGGCGRAKS RPGSPVLPPG APKAPGAGAL QLSPASPLTD QPASSQDCSE DEEDEEIDVD
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 90%.
靶标信息
LBX1 is the transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: lady bird-like homeobox; ladybird homeobox homolog 1; Ladybird homeobox protein homolog 1; Transcription factor LBX1; transcription factor similar to D. melanogaster homeodomain protein lady bird late
基因别名: homeobox; HPX-6; HPX6; LBX1; LBX1H
UniProt ID: (Human) P52954
Entrez Gene ID: (Human) 10660
分子生物学功能:
helix-turn-helix transcription factor
homeodomain transcription factor
DNA-binding transcription factor
gene-specific transcriptional regulator
heart looping
transcription, DNA-templated
muscle organ development
negative regulation of cell proliferation
anatomical structure morphogenesis
spinal cord motor neuron differentiation
regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
negative regulation of neuron differentiation
neuron fate determination
